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can try any small size controller for wearable electronics. you can go for some arduino compatible controller like lillypad for fast and easy prototyping
graphic LCD can be easily interfaced with Arduino. There is a library available for interfacing graphic LCDs with Arduino at playground.arduino.cc/Code/GLCDks0108. for creating anmation you will need to convert image files to hex (.xbm format) using GIMP or other image processing software. for loading images on arduino, you will need to load hex code of each image as character array and then use standard library functions to draw each image one after the other
For multi-layer PCBs, SMD is better option than THM as it eases routing. THM have only advantage over SMD in case, the attachment has to tolerate mechanical stress. to avoid stray capacitance and inductance, faraday shield is the best option. to minimize impact of high frequency, proper decoupling must be done.